منابع مشابه
The mechanics of development: Models and methods for tissue morphogenesis.
Embryonic development is a physical process during which groups of cells are sculpted into functional organs. The mechanical properties of tissues and the forces exerted on them serve as epigenetic regulators of morphogenesis. Understanding these mechanobiological effects in the embryo requires new experimental approaches. Here we focus on branching of the lung airways and bending of the heart ...
متن کاملTissue mechanics regulate brain development, homeostasis and disease.
All cells sense and integrate mechanical and biochemical cues from their environment to orchestrate organismal development and maintain tissue homeostasis. Mechanotransduction is the evolutionarily conserved process whereby mechanical force is translated into biochemical signals that can influence cell differentiation, survival, proliferation and migration to change tissue behavior. Not surpris...
متن کاملTissue mechanics.
The human body, from an engineering point of view, is a load-transmitting mechanism. It is subjected to self-originated and/or environmentally-imposed actions (Abrahams 1965, Paul 1967). These in turn manifest themselves in actions on tissue, and the tissue’s capability to withstand and transmit the corresponding loads through deforming appropriately can be characterized in health and disease. ...
متن کاملVertex models: from cell mechanics to tissue morphogenesis
Tissue morphogenesis requires the collective, coordinated motion and deformation of a large number of cells. Vertex model simulations for tissue mechanics have been developed to bridge the scales between force generation at the cellular level and tissue deformation and flows. We review here various formulations of vertex models that have been proposed for describing tissues in two and three dim...
متن کاملTissue patterning and cellular mechanics
In development, cells organize into biological tissues through cell growth, migration, and differentiation. Globally, this process is dictated by a genetically encoded program in which secreted morphogens and cell-cell interactions prompt the adoption of unique cell fates. Yet, at its lowest level, development is achieved through the modification of cell-cell adhesion and actomyosin-based contr...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2016
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2015.11.041